甲状腺素保护自然衰老动物海马区胆碱能神经元功能的转化医学意义

甲状腺素保护自然衰老动物海马区胆碱能神经元功能的转化医学意义

甲状腺素能否用于自然衰老动物改善其存活率和保护神经元的功能？中国西南大学药学院付爱玲教授所在团队一项动物实验表明，将小剂量的左旋甲状腺素给予老年小鼠，3个月内老年小鼠表现出明显的认知能力改善，存活率从60%提高到93%。机制研究表明，左旋甲状腺素可提高大脑海马神经元中乙酰胆碱能神经功能，这种神经元与衰老和学习记忆密切相关；此外，左旋甲状腺素还提高了神经元中抗氧酶超氧化物歧化酶的活性，并刺激海马神经元中细胞骨架重排，促进突触功能。这些结果提示，为老年动物补充少量的左旋甲状腺素可能是改善认知区神经元功能的一种好方法，这项结果也具有很好的转化医学意义和价值。相关文献发表于《中国神经再生研究（英文版）》杂志2014年4月第8期。

Article: \" The synthetic thyroid hormone, levothyroxine, protects cholinergic neurons in the hippocampus of

naturally aged mice,\" by Ailing Fu, Rumei Zhou, Xingran Xu (School of Pharmaceutical Sciences, Southwest University,

Chongqing, China)

Fu AL, Zhou RM, Xu XR. The synthetic thyroid hormone, levothyroxine, protects cholinergic neurons in the hippocampus of naturally aged mice. Neural Regen Res. 2014;9(8):864-871.

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Neural Regen Res

SICENCE新闻发布 作者：付爱玲 稿号：N201304016

Thyroid hormone protects hippocampal cholinergic neurons in normal aged animals

Can thyroid hormone protect neuronal function and increase the survival rate of naturally aged animals? Prof. Ailing Fu and her team, School of Pharmaceutical Sciences, Southwest University, China performed an animal experiment in which aged mice were administered with low dose of levothyroxine for 3 consecutive months. Results showed that the aged rats exhibited an obvious improvement in cognitive and an increased rat survival rate from 60% to 93%. The underlying mechanism was demonstrated that levothyroxine treatment can increase the levels of choline acetyltransferase and acetylcholine in hippocampal neurons, which are closely related to aging and learning and memory abilities. In addition, levothyroxine also increased superoxide dismutase activity in the hippocampal neurons, improved hippocampal cytoskeletal rearrangement and advanced synapse function. These findings suggest that supplement of low-dose levothyroxine may be a potential therapeutic strategy for normal age-related cognitive deficits. These outcomes are of encouraging translational medicine significance and value. These findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).

Article: \" The synthetic thyroid hormone, levothyroxine, protects cholinergic neurons in the hippocampus of naturally aged mice,\" by Ailing Fu, Rumei Zhou, Xingran Xu (School of Pharmaceutical Sciences, Southwest University, Chongqing, China)

Fu AL, Zhou RM, Xu XR. The synthetic thyroid hormone, levothyroxine, protects cholinergic neurons in the hippocampus of naturally aged mice. Neural Regen Res. 2014;9(8):864-871.