Benzofuran carboxamides and their therapeutic use

专利名称：Benzofuran carboxamides and their

therapeutic use

发明人：HAZEL JOAN DYKE,HANNAH JAYNE

KENDALL,JOHN GARY

MONTANA,CHRISTOPHER LOWE

申请号：AU7161600申请日：20001115公开号：AU7161600A公开日：20010628

摘要：A compound of general formula (i) wherein Z is CO or CS; R1 represents alkoxyoptionally substituted with one or more halogens, OH or thioalkyl; R2 and R3 are thesame or different and are each H, R6, OR10, COR6, C(=NOR6)R6, alkyl-C(=NOR6)R6, alkyl-C(=NOH)R6, C(=NOH)R6, halogen, NR8R9, CF3, CN, CO2H, CO2R10, CONH2, CONHR6 orCON(R6)2; R4 represents H, arylalkyl, heteroarylalkyl, heterocycloalkyl, S(O)mR10 oralkyl optionally substituted with one or more substituents chosen from hydroxy, alkoxy,CO2R7, SO2NR11R12, CONR11R12, CN, carbonyl oxygen, NR8R9, COR10 and S(O)nR10; R5represents aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl or heterocycloalkyl; inR4 and/or R5 the aryl/heteroaryl/heterocyclo portion is optionally substituted with oneor more substituents alkyl-R13 or R13; R6 represents R10 optionally substituted at anyposition with R14; R7 represents H, alkyl, arylalkyl, heteroarylalkyl or heterocycloalkyl;R8 represents H, aryl, heteroaryl, heterocyclo, alkyl, cycloalkyl, arylalkyl, heteroarylalkyl,heterocycloalkyl, alkylcarbonyl, alkoxycarbonyl, arylsulphonyl, heteroarylsulphonyl,heterocyclosulphonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl or

alkylsulphonyl; R10 represents alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl,heteroarylalkyl or heterocycloalkyl; R9, R11 and R12 are the same or different and areeach H or R10; R13 represents alkyl optionally substituted with halogen, alcoxyoptionally substituted by halogen, aryl, heteroaryl, heterocyclo, hydroxy, aryloxy,heteroaryloxy, heterocyclooxy, arylalkyloxy, heteroarylalkyloxy, heterocycloalkoxy,CO2R7, CONR11R12, SO2NR11R12, halogen, -CN, -NR8R9, COR10, S(O)nR10 or carbonyloxygen; R14 represents OH, carbonyl oxygen, OR10, NR8R9, CN, CO2H, CO2R10,CON11R12 or COR10; m is an integer of up to 2; and n represents 0-2, or apharmaceutically acceptable salt thereof.

申请人：DARWIN DISCOVERY LIMITED

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