Product Data SheetPdtDtShtProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Mefloquine hydrochloride51773-92-3HY-17437A414.77C17H17ClF6N2O>98%Solubility:25°C: DMSOMechanisms: Pathways:Anti-infection; Target:Antiparasitic Biological Activity:Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to theantiarrhythmic agent quinidine. IC50 Value: 1 microM ( for K+ channel) [1] Target: Antiparasitic Mefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria.MQ can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS)may be used as a therapeutic modality to kill cancer cells [2]. in vitro: Mefloquine inhibitedKvLQT1/minK channel currents with an IC50 value of approximately 1microM. Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident atlowermembranepotentialscomparedwithhigheronesHERGchannelcurrentswereabout6-foldlower membrane potentials compared with higher ones. HERG channel currents were about 6-foldless sensitive to block by mefloquine (IC50 = 5.6 microM). Block of HERG displayed a positivevoltage dependence with maximal inhibition obtained a...References:[1]. Kang J, Chen XL, Wang L, Interactions of the antimalarial drug mefloquine with the humancardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001Oct;299(1):2906 Oct;299(1):290-6.[2]. Yan KH, Yao CJ, Hsiao CH, Mefloquine exerts anticancer activity in prostate cancer cells viaROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. [3]. Boareto AC, Müller JC, Louren?o EL, Effects of the combined artesunate and mefloquineantimalarial drugs on rat embryos. Hum Exp Toxicol. 2013 Feb 19. [Epub ahead of print] Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr